Toxicity. Toxic amounts of magnesium can cause problems with the kidneys. It may also cause severe reactions that affect the intestines. One condition called ischemic colitis can cause permanent damage to the intestines, and it has been linked to magnesium toxicity.
Too much magnesium from foods isn't a concern for healthy adults. However, the same can't be said for supplements. High doses of magnesium from supplements or medications can cause nausea, abdominal cramping and diarrhea.
Magnesium helps to increase the amount of water in the intestines, which can help with bowel movements. It may be used as a laxative due to these properties, or as a supplement for magnesium deficiency.
Magnesium can also be taken as a laxative to help relieve constipation. Magnesium-based laxatives belong to a class of laxatives called saline osmotics. They work by drawing water into the bowels to trigger bowel movements and make them easier to pass.
People with diabetes, intestinal disease, heart disease or kidney disease should not take magnesium before speaking with their health care provider. Overdose. Signs of a magnesium overdose can include nausea, diarrhea, low blood pressure, muscle weakness, and fatigue. At very high doses, magnesium can be fatal.
Results: We found that total magnesium consumption was linked to a significantly lower risk of colorectal adenoma, particularly in those subjects with a low Ca:Mg intake. An inverse association trend was found for hyperplastic polyps.
It's been shown, says Dr. Farhadi, that foods rich in magnesium can prevent the progression of diverticulosis—but be aware that some of these foods are nuts, and you may be limited in eating them if they're a trigger food for you. As far as other vitamins, some patients with diverticulitis wonder about vitamin D.
Taking a magnesium supplement to address a deficiency has been linked to health benefits. These include improvements in blood pressure, mood, and blood sugar management, as well as a lower risk of developing health conditions such as heart disease.
Kogan says. "But magnesium helps relax these muscles and that leads to feeling much better." (You may actually be using magnesium to treat your IBS without realizing it: The active ingredient in the popular constipation reliever Milk of Magnesia is magnesium hydroxide.)
Magnesium is essential for many aspects of health. The recommended daily intake is 400–420 mg per day for men and 310–320 mg per day for women ( 40 ). You can get this mineral from both food and supplements.
"Some forms of magnesium supplements, such as carbonate, chloride, gluconate, oxide, and citrate form salts that draw water into the gut, leading to diarrhea—an osmotic effect of the magnesium salt," explains Sasse.
The National Academy of Medicine recommends not exceeding 350 mg of supplemental magnesium per day ( 2 ). However, several studies have involved higher daily dosages. It's recommended to only take a daily magnesium supplement that provides more than 350 mg while under medical supervision.
Low extracellular Mg also affects normal stromal cells that can release growth factors and proteases, thus potentiating tumour growth and development. In addition, in vivo low Mg activates an inflammatory response, which has many tumour-promoting effects.
The team found that a combination of Vitamin A acetate (RAc) and TRAIL, short for tumor necrosis factor-related apoptosis-inducing ligand, kills precancerous polyps and inhibits tumor growth in mice that have deficiencies in a tumor-suppressor gene.
Taking a multivitamin -- most of which contain 400 IUs of vitamin D -- was associated with reducing polyp risk by about 25%. These multivitamins also contain adequate amounts of calcium, folate, vitamin E, and selenium, which Lieberman also found to help lower polyp risk, "but not as much as vitamin D," he says.
An older 2003 study of 46 adults found that magnesium citrate absorbed better than magnesium oxide and magnesium chelate. However, doctors also use magnesium citrate to treat constipation. For some people, this may mean it causes unwanted digestive side effects, such as diarrhea.
While you can take magnesium in the hours before bedtime, as is recommended for melatonin, you can alternatively take magnesium supplements during the day. The time you take magnesium often depends on any other medications you are taking.
Others -- Aminoglycoside antibiotics (such as gentamicin and tobramycin), thiazide diuretics (such as hydrochlorothiazide), loop diuretics (such as furosemide and bumetanide), amphotericin B, corticosteroids (prednisone or Deltasone), antacids, and insulin may lower magnesium levels.